Viswanath Das and John H. Miller Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation European Journal of Neuroscience 35
Article first published online: 17 MAY 2012 | DOI: 10.1111/j.1460-9568.2012.08084.x
Many cellular organelles must travel long distances in neurons to perform their specific functions, and this transport is highly dependent on the microtubule network within the axon. Hyperphosphorylation of microtubule-associated tau protein destabilizes microtubules and leads to neuronal cell death.
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