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Nada Yousif, Roman Borisyuk, Nicola Pavese, Dipankar Nandi and Peter Bain Spatiotemporal visualization of deep brain stimulation-induced effects in the subthalamic nucleus European Journal of Neuroscience 36

Article first published online: 17 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08086.x

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We used a computational model to study the effect of deep brain stimulation on the spiking activity of a bursting subthalamic nucleus neuron, hypothesizing that the firing mode of the cell will have a major impact. Our simulations showed that the model exhibits a silent period at stimulation offset and frequency-dependent effects. Our results demonstrated a method of quantitatively assessing neuronal changes induced by DBS, to maximize therapeutic benefit and minimize unwanted side effects.

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