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Jonathan E. Rubin, Cameron C. McIntyre, Robert S. Turner and Thomas Wichmann Basal ganglia activity patterns in parkinsonism and computational modeling of their downstream effects European Journal of Neuroscience 36

Version of Record online: 17 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08108.x

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Parkinsonism has been linked with changes in neuronal firing patterns in the basal ganglia (BG) and associated areas of the thalamus and cortex. We provide an overview of these findings and discuss some efforts to use computational models to understand these relationships as well as the therapeutic effects of deep brain stimulation (DBS). In particular, several modeling studies that we consider focus on the idea that DBS works by regularizing BG outputs. For example, models show how parkinsonian basal ganglia outputs may compromise thalamocortical relay of excitatory inputs (curly brackets), while DBS- induced regularization may restore relay fidelity, and these ideas lead to predictions about the importance of particular BG outputs in the emergence of parkinsonian signs and of particular DBS properties in alleviating these signs.

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