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Laura Clarke, Brian G. Ballios and Derek van der Kooy Generation and clonal isolation of retinal stem cells from human embryonic stem cells European Journal of Neuroscience 36

Version of Record online: 16 MAY 2012 | DOI: 10.1111/j.1460-9568.2012.08123.x

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Retinal stem cells (RSCs) are present within the pigmented ciliary epithelium (CE) of the adult human eye and produce progeny that differentiate in vitro into all neural retinal subtypes and retinal pigmented epithelium (RPE). We hypothesized that a RSC population, similar to the adult CE-derived RSC, is contained within pigmented colonies that arise in long-term cultures of human embryonic stem cells (hESCs) suggested to recapitulate retinal development in vitro.

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