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Etsuko Suzuki and Takashi Okada Stratum oriens stimulation-evoked modulation of hippocampal long-term potentiation involves the activation of muscarinic acetylcholine receptors and the inhibition of Kv7/M potassium ion channels European Journal of Neuroscience 36

Article first published online: 28 MAY 2012 | DOI: 10.1111/j.1460-9568.2012.08127.x

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The activation of muscarinic acetylcholine receptors (mAChRs) reportedly enhances hippocampal synaptic plasticity; however, the mechanism by which it enhances synaptic plasticity remains unclear. Here, authors propose that stratum oriens stimulation inhibits Kv7/M K+ channels through mAChR activation-induced phospholipase C activation, which leads to voltage-dependent Ca2+ channel activation, and hence causes sufficient Ca2+ influx to enhance long-term potentiation at hippocampal CA1 area.

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