Etsuko Suzuki and Takashi Okada Stratum oriens stimulation-evoked modulation of hippocampal long-term potentiation involves the activation of muscarinic acetylcholine receptors and the inhibition of Kv7/M potassium ion channels European Journal of Neuroscience 36
Article first published online: 28 MAY 2012 | DOI: 10.1111/j.1460-9568.2012.08127.x
The activation of muscarinic acetylcholine receptors (mAChRs) reportedly enhances hippocampal synaptic plasticity; however, the mechanism by which it enhances synaptic plasticity remains unclear. Here, authors propose that stratum oriens stimulation inhibits Kv7/M K+ channels through mAChR activation-induced phospholipase C activation, which leads to voltage-dependent Ca2+ channel activation, and hence causes sufficient Ca2+ influx to enhance long-term potentiation at hippocampal CA1 area.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf