Patricio O’Donnell Cortical interneurons, immune factors and oxidative stress as early targets for schizophrenia European Journal of Neuroscience 35
Article first published online: 19 JUN 2012 | DOI: 10.1111/j.1460-9568.2012.08130.x
Cortical interneurons are affected in schizophrenia, and animal models reveal their protracted developmental trajectory is affected by diverse manipulations, yielding behavioral anomalies with a peri-adolescent onset. Immune activation and oxidative stress are likely factors that contribute to GABA interneuron alterations during development in these models and perhaps in schizophrenia as well. These observations suggest novel preventive approaches may be identified with translational efforts.
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