Julia Fuchs, Olivier Stettler, Daniel Alvarez-Fischer, Alain Prochiantz, Kenneth L. Moya and Rajiv L. Joshi Engrailed signaling in axon guidance and neuron survival European Journal of Neuroscience 35
The study of Engrailed signaling in retinal axon guidance and in the survival of adult dopaminergic neurons has revealed an unsuspected link between a homeoprotein and mitochondrial activity. Engrailed-mediated effects involve translation regulation as well as cooperation with classical signaling pathways. These findings highlight the crucial role of cellular energy metabolism in neuron development, survival and neurodegeneration, and may help to identify novel therapeutic targets.
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