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Xiao-Dong Wang, Christiana Labermaier, Florian Holsboer, Wolfgang Wurst, Jan M. Deussing, Marianne B. Müller and Mathias V. Schmidt Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1 European Journal of Neuroscience 36

Version of Record online: 4 JUN 2012 | DOI: 10.1111/j.1460-9568.2012.08148.x

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Forebrain corticotropin-releasing hormone receptor 1 (CRHR1) may modulate the anxiogenic effects of early-life stress. Here we report that early-life stress-evoked anxiety-related behavior in adult mice can be partially prevented by postnatal deletion of CRHR1 in forebrain neurons. Moreover, in stressed animals, forebrain CRHR1 inactivation attenuates body weight loss during development and adulthood, and accelerates recovery to acute stress challenge.

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