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David A. Lewis Cortical circuit dysfunction and cognitive deficits in schizophrenia – implications for preemptive interventions European Journal of Neuroscience 35

Version of Record online: 19 JUN 2012 | DOI: 10.1111/j.1460-9568.2012.08156.x

Schizophrenia is a common, usually chronic, and very costly illness with no proven means of prevention. Impairments in certain cognitive processes are the core feature of schizophrenia, reflect abnormalities in specific cortical circuits, and arise during childhood-adolescence. The implications of these findings for the development of preemptive, disease-modifying interventions in individuals at high risk for a clinical diagnosis of schizophrenia are discussed.

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