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Ghislaine Caillol, Hélène Vacher, Magali Musarella, Sarah Bellouze, Bénédicte Dargent and Amapola Autillo-Touati Motor endplate disease affects neuromuscular junction maturation European Journal of Neuroscience 36

Version of Record online: 30 MAY 2012 | DOI: 10.1111/j.1460-9568.2012.08164.x

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The med (motor endplate disease) mouse phenotype appears at a crucial stage of the neuromuscular junction (NMJ) development. In the med mice, there is a drastic decrease in Terminal Schwann Cells (TSC) number, persistent multiple-innervation and a defect in synaptic maturation. All together these findings suggest that the med pathology is related to NMJ postnatal structural developmental defects probably triggered by the progressive loss of the TSCs and an ineffective synaptic maturation.

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