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Dmitry. M. Mebel, Jovi. C. Y. Wong, Yifei. J. Dong and Stephanie. L. Borgland Insulin in the ventral tegmental area reduces hedonic feeding and suppresses dopamine concentration via increased reuptake European Journal of Neuroscience 36

Version of Record online: 19 JUN 2012 | DOI: 10.1111/j.1460-9568.2012.08168.x

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Insulin causes a long-lasting decrease in somatodendritic dopamine concentration in the VTA due to an increase in dopamine reuptake via dopamine transporters. Insulin suppresses somatodendritic dopamine concentration only at burst-like frequencies, suggesting the possibility that insulin suppresses dopamine during times of discrete cues which typically induce burst firing. Consistent with this, insulin action in the VTA attenuates hedonic but not hungry feeding.

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