Noemí Esteras, Fernando Bartolomé, Carolina Alquézar, Desireé Antequera, Úrsula Muñoz, Eva Carro and Ángeles Martín-Requero Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer’s disease [amyloid precursor protein/presenilin 1 (PS1)] European Journal of Neuroscience 36
Article first published online: 15 JUN 2012 | DOI: 10.1111/j.1460-9568.2012.08178.x
By using cell cycle pathway-specific RT2ProfilerTM PCR Arrays, we have detected changes in a number of cell cycle-related genes in brain and in lymphocytes from APP/PS1 mice. Moreover, we have found enhanced BrdU incorporation into DNA in lymphocytes from APP/PS1 mice, and increased expression of cell cycle-related proteins, as detected by immunohistochemistry in cortical neurons of the APP/PS1 mice. These observations support the mitosis failure hypothesis in AD and demonstrate the existence of systemic manifestations of the disease.
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