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Annabelle Reaux-Le Goazigo, Cyril Rivat, Patrick Kitabgi, Michel Pohl and Stéphane Melik Parsadaniantz Cellular and subcellular localization of CXCL12 and CXCR4 in rat nociceptive structures: physiological relevance European Journal of Neuroscience 36

Version of Record online: 14 JUN 2012 | DOI: 10.1111/j.1460-9568.2012.08179.x

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We demonstrate that an intrathecal CXCL12 administration increases mechanical sensitivity in naïve rats. By light/electron microscopic immunohistochemistry, we evidence the CXCL12/CXCR4 trafficking and vesicular sorting in nociceptors. CXCR4 are localized at pre- and post-synaptic sites of primary afferents terminals. The presence of CXCL12/CXCR4-IR in nociceptors reinforces the concept that noxious stimulus-evoked release of CXCL12 participates in nociceptive signaling through CXCR4 present on both primary afferents and second-order neurons in the spinal cord.

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