Qian Chen, Jeffrey H. Kogan, Adam K. Gross, Yuan Zhou, Noah M. Walton, Rick Shin, Carrie L. Heusner, Shinichi Miyake, Katsunori Tajinda, Kouichi Tamura and Mitsuyuki Matsumoto SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent learning and memory European Journal of Neuroscience 36
As a schizophenia risk factor, SREB2 gene is highly expressed in brain, especially in the dentate gyrus. However, the function of SREB2 in hippocampus is largely unknown. By employing SREB2 mutant mice (SREB2 Tg and KO mice) in our research, we demonstrated that SREB2 negatively regulated hippocampal adult neurogenesis and affected the consequential cognitive functions.
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