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Paul H. E. Tiesinga Motifs in health and disease: the promise of circuit interrogation by optogenetics European Journal of Neuroscience 36

Article first published online: 17 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08186.x

Thumbnail image of graphical abstract

Model simulations suggest that optogenetics can be used to discover and characterize dynamical motifs responsible for cortical oscillations and identify defects in them that could underlie psychiatric illnesses. The image shows responses from a cortical network in a state characterized by two time scales, a slow intrinsic one due to pyramidal cells and a fast one due to fast GABAergic inhibition, both of which lead to resonances in response to periodic optogenetic stimulation.

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