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David Yang, Michael Chen and Amelia Russo-Neustadt Antidepressants are neuroprotective against nutrient deprivation stress in rat hippocampal neurons European Journal of Neuroscience 36

Article first published online: 11 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08187.x

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Norepinephrine, serotonin, and three antidepressants increased cell survival and the immunoreactivity of several intracellular survival proteins, such as BDNF, P-Akt, PI-3K, and P-CREB. However, under the same conditions, but without certain key nutrients, only P-Akt levels showed signs of decreasing. Inhibiting these pro-survival pathways, however, decreased cell survival and most of these survival proteins (not P-Akt), relative to those under conditions of nutrient supplement.

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