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Sanaz Gabery, Muhammad U. Sajjad, Sofia Hult, Rana Soylu, Deniz Kirik and Åsa Petersén Characterization of a rat model of Huntington’s disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors European Journal of Neuroscience 36

Version of Record online: 25 JUN 2012 | DOI: 10.1111/j.1460-9568.2012.08193.x

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Injections of recombinant adeno-associated viral vectors of serotype 5 (rAAV5) expressing an 853 amino acid fragment of huntingtin (htt) with either 79 (mutant) or 18 (wild-type) glutamines (Q) in the dorsal striatum of neonatal rats lead to widespread expression of htt in the forebrain. Neuropathological analysis at 6 months showed long-term expression of the GFP transgene (used as a marker protein) and htt inclusions in the cerebral cortex of rats with the rAAV5-htt-79Q vectors

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