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Bryan W. Camp, Julia E. Gerson, Candy Wing S. Tsang, Stephanie R. Villa, Jazmin I. Acosta, B. Blair Braden, Ann N. Hoffman, Cheryl D. Conrad and Heather A. Bimonte-Nelson High serum androstenedione levels correlate with impaired memory in the surgically menopausal rat: a replication and new findings European Journal of Neuroscience 36

Article first published online: 3 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08194.x

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Androstenedione is the primary ovary-derived hormone during menopause. Prior work in rats showed that higher endogenous serum androstenedione levels correlated with poorer memory scores after follicular depletion. The current study tested cognitive effects of androstenedione administration in the middle-aged ovariectomised rat. Androstenedione impaired spatial reference memory, working memory, and memory retention. Results indicate that androstenedione can impact memory in females during middle-age.

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