F. U. Hohlefeld, J. Huebl, C. Huchzermeyer, G.-H. Schneider, T. Schönecker, A. A. Kühn, G. Curio and V. V. Nikulin Long-range temporal correlations in the subthalamic nucleus of patients with Parkinson’s disease European Journal of Neuroscience 36
The present study demonstrated that neuronal oscillations in the subthalamic nucleus of patients with Parkinson’s disease (PD) are characterised by long-range temporal correlations (LRTC) extending up to 50 s, which were found to be decreased after levodopa withdrawal in the beta (13–35 Hz) and high-frequency oscillations (approximately 300 Hz). This might indicate limited information processing in the dopamine-depleted basal ganglia, implying LRTC as a biomarker of pathological neuronal processes in PD.
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