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F. U. Hohlefeld, J. Huebl, C. Huchzermeyer, G.-H. Schneider, T. Schönecker, A. A. Kühn, G. Curio and V. V. Nikulin Long-range temporal correlations in the subthalamic nucleus of patients with Parkinson’s disease European Journal of Neuroscience 36

Version of Record online: 2 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08198.x

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The present study demonstrated that neuronal oscillations in the subthalamic nucleus of patients with Parkinson’s disease (PD) are characterised by long-range temporal correlations (LRTC) extending up to 50 s, which were found to be decreased after levodopa withdrawal in the beta (13–35 Hz) and high-frequency oscillations (approximately 300 Hz). This might indicate limited information processing in the dopamine-depleted basal ganglia, implying LRTC as a biomarker of pathological neuronal processes in PD.

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