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Marcus E. Petersson and Erik Fransén Long-lasting small-amplitude TRP-mediated dendritic depolarizations in CA1 pyramidal neurons are intrinsically stable and originate from distal tuft regions European Journal of Neuroscience 36

Version of Record online: 3 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08199.x

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In vitro studies of pyramidal neurons have reported long-lasting small-amplitude depolarizations. In this work, we show that these depolarizations may originate from distal apical tuft dendrites. We also show that the underlying mechanism (which involves TRP and VGCC currents) is intrinsically stable to weak excitatory and inhibitory input, thereby providing the cell with a mechanism for subthreshold dendritic bistability. We further discuss the impact on synaptic integration.

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