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Christopher Bishop, Jessica A. George, William Buchta, Adam A. Goldenberg, Mohamed Mohamed, Sando O. Dickinson, Satie Eissa and Karen L. Eskow Jaunarajs Serotonin transporter inhibition attenuates l-DOPA-induced dyskinesia without compromising l-DOPA efficacy in hemi-parkinsonian rats European Journal of Neuroscience 36

Version of Record online: 5 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08202.x

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Long-term l-DOPA replacement therapy in Parkinson’s disease often leads to the development of l-DOPA-induced dyskinesia. Growing evidence suggests that serotonin receptors may constitute therapeutic targets for the reduction of these abnormal involuntary movements. The current work demonstrates that serotonin transporter inhibition can also attenuate l-DOPA-induced dyskinesia without affecting l-DOPA efficacy.

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