Maria C. Monti, Laura A. Gabach, Mariela F. Perez and Oscar A. Ramírez Impact of contextual cues in the expression of the memory associated with diazepam withdrawal: involvement of hippocampal PKMζin vivo, and Arc expression and LTP in vitro European Journal of Neuroscience 36
The memory associated with diazepam withdrawal can be affected by changes in the contextual cues presented during withdrawal and by direct interference of hippocampal synaptic plasticity using a PKMζ inhibitor. The context associated to drug experience is relevant for the expression of withdrawal signs and the associated enhanced hippocampal synaptic plasticity. These mechanisms can be used to prevent or treat drug dependence or addiction.
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