Andrew Sherwood, Marlena Wosiski-Kuhn, Truc Nguyen, Peter C. Holland, Bernard Lakaye, Antoine Adamantidis and Alexander W. Johnson The role of melanin-concentrating hormone in conditioned reward learning European Journal of Neuroscience 36
The Melanin Concentrating Hormone (MCH) is well-positioned to play a key role in connecting brain reward and homoeostatic systems. Here we investigated in mice whether deletion or pharmacological antagonism of the MCH receptor would disrupt two putative forms of reward-learning: conditioned reinforcement and Pavlovian-instrumental transfer. Our results suggest a role for MCH in guiding behavior based on the conditioned reinforcing value of a cue.
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