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Andrew Sherwood, Marlena Wosiski-Kuhn, Truc Nguyen, Peter C. Holland, Bernard Lakaye, Antoine Adamantidis and Alexander W. Johnson The role of melanin-concentrating hormone in conditioned reward learning European Journal of Neuroscience 36

Version of Record online: 8 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08207.x

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The Melanin Concentrating Hormone (MCH) is well-positioned to play a key role in connecting brain reward and homoeostatic systems. Here we investigated in mice whether deletion or pharmacological antagonism of the MCH receptor would disrupt two putative forms of reward-learning: conditioned reinforcement and Pavlovian-instrumental transfer. Our results suggest a role for MCH in guiding behavior based on the conditioned reinforcing value of a cue.

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