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Eleanor J. Waite, Mervyn McKenna, Yvonne Kershaw, Jamie J. Walker, Kwangwook Cho, Hugh D. Piggins and Stafford L. Lightman Ultradian corticosterone secretion is maintained in the absence of circadian cues European Journal of Neuroscience 36

Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08213.x

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Our studies investigate the importance of the SCN in regulating ultradian rhythmicity. Both SCN-lesioning and constant light exposure resulted in a loss of the circadian pattern of corticosterone secretion, whereas the ultradian pulsatile secretion of corticosterone was maintained across the 24 h in all animals. Furthermore, the loss of SCN input revealed an underlying relationship between locomotor and HPA activity.

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