Thomas J. Ha, Douglas J. Swanson, Roumyana Kirova, Joanna Yeung, Kunho Choi, Yiai Tong, Elissa J. Chesler and Daniel Goldowitz Genome-wide microarray comparison reveals downstream genes of Pax6 in the developing mouse cerebellum European Journal of Neuroscience 36
Article first published online: 22 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08221.x
We performed transcriptome profiling on Pax6-null and Math1-null cerebella and the intersection of these two datasets produced a total of 21 differentially regulated transcripts. We validated the expression of these transcripts in the cells that arise from the rhombic lip and their differential expression in Pax6-null cerebellum with qRT-PCR and ISH analyses. The candidate genes identified in this way represent direct or indirect Pax6-downstream genes involved in cerebellar development.
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