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Mariya Vasileva, Heinz Horstmann, Constanze Geumann, Daniel Gitler and Thomas Kuner Synapsin-dependent reserveo pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission European Journal of Neuroscience 36

Article first published online: 16 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08225.x

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We examined the morphological and functional consequences of deleting all synapsin isoforms at the calyx of Held synapse. Our results suggest that in wild-type synapses, only a small fraction of the synapsin-dependent reserve pool of vesicles enters the readily releasable pool. Synapsins are required for normal synaptic vesicle biogenesis, trafficking and immobilization of synaptic vesicles, yet they are not essential for sustained high-frequency synaptic transmission at the calyx terminal.

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