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Hongying Wei and Monika Stengl Ca2+-dependent ion channels underlying spontaneous activity in insect circadian pacemaker neurons European Journal of Neuroscience 36

Version of Record online: 22 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08227.x

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Insect circadian pacemaker neurons express rhythmic action potential activity in the gamma frequency range of 20–70 Hz together with circadian rhythmicity. Employing FURA 2-dependent calcium imaging we characterised ion channels underlying spontaneous activity. We found that mostly mibefradil-sensitive, low-voltage-activated calcium channels, but not slow inactivating sodium pacemaker channels are responsible for the regular spontaneous activity. Now, it can be examined whether gamma-band rhythmic activity is affecting the nuclear circadian clockwork or whether it solely affects clock outputs.

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