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Daniel L. Hummer, Elizabeth M. Peckham and Theresa M. Lee Estradiol acts during a post-pubertal sensitive period to shorten free-running circadian period in male Octodon degus European Journal of Neuroscience 36

Version of Record online: 15 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08228.x

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The administration of estradiol during a sensitive period of post-pubertal development decreases the free-running circadian period of males but not females, resulting in a permanent sexual dimorphism in the circadian timekeeping mechanism of Octodon degus. These data demonstrate that gonadal hormones can act during adolescent development to permanently alter the circadian system.

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