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Orbicia Riccio, Nicolas Hurni, Sahana Murthy, Laszlo Vutskits, Lutz Hein and Alexandre Dayer Alpha2-adrenergic receptor activation regulates cortical interneuron migration European Journal of Neuroscience 36

Version of Record online: 17 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08231.x

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Monoamines such as serotonin and dopamine regulate cortical interneuron migration but very little is known regarding noradrenaline. In this study we monitored the effects of adrenergic receptor stimulation on interneuron migration in cortical slices and found that adra2 receptor activation inhibits the migration of cortical interneurons in a concentration-dependent and reversible manner. Furthermore the distribution of cortical interneurons was altered in vivo in adra2a/2c knock-out mice.

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