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Joana Gonçalves, Carlos F. Ribeiro, João O. Malva and Ana P. Silva Protective role of neuropeptide Y Y2 receptors in cell death and microglial response following methamphetamine injury European Journal of Neuroscience 36

Version of Record online: 17 JUL 2012 | DOI: 10.1111/j.1460-9568.2012.08232.x

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Neuropeptide Y (NPY) has a protective effect against METH-induced neuronal cell death in mouse organotypic slice cultures via Y2 receptors. This effect involves changes in pro- and anti-apoptotic protein levels, Bcl-2 and Bax, respectively. We also showed that METH triggers a microglial response, which was once again prevented by the activation of Y2 receptors. Overall, the present study suggests this NPY receptor subtype as a promising tool to prevent cell death induced by METH.

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