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Melanie A. Paquette, Alex A. Martinez, Teresa Macheda, Charles K. Meshul, Steven W. Johnson, S. Paul Berger and Andrea Giuffrida Anti-dyskinetic mechanisms of amantadine and dextromethorphan in the 6-OHDA rat model of Parkinson’s disease: role of NMDA vs. 5-HT1A receptors European Journal of Neuroscience 36

Version of Record online: 3 AUG 2012 | DOI: 10.1111/j.1460-9568.2012.08243.x

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Dextromethorphan (DM) suppressed L-DOPA-induced AIMs. This effect was blocked by the 5-HT1A antagonist WAY-100635 (WAY), but not the NMDA agonist D-cycloserine (DCS). *P < 0.05 relative to vehicle (Veh); #< 0.01 relative to DM, +P < 0.001 relative to DCS.

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