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Hanieh Toossi, Esther Del Cid-Pellitero, Thomas Stroh and Barbara E. Jones Somatostatin varicosities contain the vesicular GABA transporter and contact orexin neurons in the hypothalamus European Journal of Neuroscience 36

Version of Record online: 24 AUG 2012 | DOI: 10.1111/j.1460-9568.2012.08253.x

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Somatostatin (SST) is a neuropeptide with known inhibitory actions in the hypothalamus, where it inhibits release of growth hormone releasing hormone (GHRH), while also influencing the sleep-wake cycle. Here, we investigated in the rat whether SST neurons might additionally release GABA or glutamate in different regions and whether they might contact orexin neurons that play an important role in the maintenance of wakefulness.

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