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Fabio Sambataro, Martin Safrin, Herve S. Lemaitre, Sonya U. Steele, Saumitra B. Das, Joseph H. Callicott, Daniel R. Weinberger and Venkata S. Mattay Normal aging modulates prefrontoparietal networks underlying multiple memory processes European Journal of Neuroscience 36

Article first published online: 21 AUG 2012 | DOI: 10.1111/j.1460-9568.2012.08254.x

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Aging is associated with memory decline. Here we investigated age-related changes in brain responses across multiple memory domains. Older subjects had a greater engagement of a prefronto-parietal-occipital network relative to younger subjects during working memory (A, B) and the encoding phase of episodic memory (C). Our findings lend support to the dedifferentiation hypothesis of cognitive aging.

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