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Liana Artinian, Lei Zhong, Hansoo Yang and Vincent Rehder Nitric oxide as intracellular modulator: internal production of NO increases neuronal excitability via modulation of several ionic conductances European Journal of Neuroscience 36

Version of Record online: 22 AUG 2012 | DOI: 10.1111/j.1460-9568.2012.08260.x

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Nitric oxide (NO) acts as a modulator of intrinsic neuronal excitability in an identified neuron of the mollusk Helisoma trivolvis. B5 neurons constitutively produce NO, which is necessary for this neuron to fire spontaneous and evoked action potentials. NO acts via up-regulation of a persistent sodium current and a voltage-gated Ca current, and by down-regulation of a small conductance Ca-activated potassium (SK) current. Only the activation of the Ca current by NO is mediated by sGC-PKG signaling.

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