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Thierry Louis, Pierre-Yves Musso, Sabrina Barbosa de Oliveira, Lucile Garreau, Martin Giurfa, Valérie Raymond and Monique Gauthier Amelα8 subunit knockdown in the mushroom body vertical lobes impairs olfactory retrieval in the honeybee, Apis mellifera European Journal of Neuroscience 36

Article first published online: 4 SEP 2012 | DOI: 10.1111/j.1460-9568.2012.08261.x

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The role of the Amelα8 nicotinic subunit in olfactory learning and memory was assessed using RNA interference. The protein was present in different brain regions involved in olfactory learning (A, B). Small interfering RNA against Amelα8 induced a 25% decrease in the protein expression 6 h after brain injection (C). Amelα8 knockdown in the mushroom body vertical lobes induced a decrease in retention performance (D) of a discriminative olfactory conditioning task linked to an impairment of retrieval processes.

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