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Sofya P. Kulikova, Elena A. Tolmacheva, Paul Anderson, Julien Gaudias, Brendan E. Adams, Thomas Zheng and Didier Pinault Opposite effects of ketamine and deep brain stimulation on rat thalamocortical information processing European Journal of Neuroscience 36

Version of Record online: 29 AUG 2012 | DOI: 10.1111/j.1460-9568.2012.08263.x

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This study tested the hypothesis that sensory deficits induced by the psychotomimetic ketamine are due to an impairment of the ability of the thalamocortical (TC) system to discriminate the relevant information from the baseline activity. A single injection of ketamine (2.5 mg/kg) increases the amount of baseline γ oscillations and decreases both the amplitude of the sensory-evoked TC response and the amount of its related γ oscillations. Thalamic high-frequency DBS has opposite effects.

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