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Paulette A. McRae, Esther Baranov, Stephanie L. Rogers and Brenda E. Porter Persistent decrease in multiple components of the perineuronal net following status epilepticus European Journal of Neuroscience 36

Version of Record online: 31 AUG 2012 | DOI: 10.1111/j.1460-9568.2012.08268.x

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In the rodent model of temporal lobe epilepsy, there is extensive synaptic reorganization within the hippocampus following a single prolonged seizure event, after which animals eventually develop epilepsy. The perineuronal net (PN), a component of the neural extracellular matrix, primarily surrounds inhibitory interneurons and under normal conditions restricts synaptic reorganization.

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