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Hugues Petitjean, Jean-Luc Rodeau and Rémy Schlichter Interactions between superficial and deep dorsal horn spinal cord neurons in the processing of nociceptive information European Journal of Neuroscience 36

Article first published online: 12 SEP 2012 | DOI: 10.1111/j.1460-9568.2012.08273.x

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The dorsal horn of the spinal cord plays an important role in the integration of somatosensory information. We show that nociceptive messages are transmitted from superficial to deep laminae of the dorsal horn by an excitatory pathway and that deep laminae exert an inhibitory feedback control over more superficial laminae. In this context laminae III–IV interneurons might play an fundamental role in the integration of nociceptive and non-nociceptive sensory messages at the spinal level.

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