Mirjam Sibbe, Ute Häussler, Sandra Dieni, Daniel Althof, Carola A. Haas and Michael Frotscher Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus European Journal of Neuroscience 36
Article first published online: 17 SEP 2012 | DOI: 10.1111/j.1460-9568.2012.08279.x
The effect of status epilepticus on the adult hippocampal stem cell niche was studied in a mouse model. Notch signaling, assayed by hes5 reporter gene activity, was diminished in the subgranular zone (SGZ) of the dentate gyrus. Sox2+ cells as well as stem cell proliferation were altered, pointing to a disruption of the stem cell niche in epilepsy. *P < 0.05, **P < 0.01.
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