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Nicole Landi, Stephen J. Frost, W. Einar Mencl, Jonathan L. Preston, Leslie K. Jacobsen, Maria Lee, Carolyn Yrigollen, Kenneth R. Pugh and Elena L. Grigorenko The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation Developmental Science 16

Version of Record online: 3 OCT 2012 | DOI: 10.1111/j.1467-7687.2012.01180.x

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In both children and adults there is large variability in reading skill, with approximately 5–10% of individuals characterized as having reading disability; these individuals struggle to learn to read despite adequate intelligence and opportunity. Although it is well established that a substantial portion of this variability is attributed to the genetic differences between individuals, specifics of the connections between reading and the genome are not understood. This article presents data that suggest that variation in the COMT gene, which has previously been associated with variation in higher-order cognition, is associated with reading and reading-related skills, at the level of both brain and behavior.

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