E-mail

E-mail a Wiley Online Library Link

Kansuke Fujiwara, Koro Gotoh, Seiichi Chiba, Takayuki Masaki, Isao Katsuragi, Tetsuya Kakuma and Hironobu Yoshimatsu Intraportal administration of DPP-IV inhibitor regulates insulin secretion and food intake mediated by the hepatic vagal afferent nerve in rats Journal of Neurochemistry 121

Version of Record online: 15 FEB 2012 | DOI: 10.1111/j.1471-4159.2011.07563.x

Thumbnail image of graphical abstract

Neuronal pathways for glucose metabolism and feeding behavior Glucagon-like peptide-1 (GLP-1), rapidly degraded by dipeptidyl peptidase-IV (DPP-IV), affects glucose metabolism and feeding behavior. DPP-IV inhibitor-induced changes in portal but not systemic GLP-1 levels stimulate insulin secretion and suppress feeding, which are blocked by vagotomy, indicating a neuronal pathway that includes the hepatic vagal afferent nerve plays an important role in the pharmacological actions of DPP-IV inhibitor.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH