Kansuke Fujiwara, Koro Gotoh, Seiichi Chiba, Takayuki Masaki, Isao Katsuragi, Tetsuya Kakuma and Hironobu Yoshimatsu Intraportal administration of DPP-IV inhibitor regulates insulin secretion and food intake mediated by the hepatic vagal afferent nerve in rats Journal of Neurochemistry 121
Article first published online: 15 FEB 2012 | DOI: 10.1111/j.1471-4159.2011.07563.x
Neuronal pathways for glucose metabolism and feeding behavior Glucagon-like peptide-1 (GLP-1), rapidly degraded by dipeptidyl peptidase-IV (DPP-IV), affects glucose metabolism and feeding behavior. DPP-IV inhibitor-induced changes in portal but not systemic GLP-1 levels stimulate insulin secretion and suppress feeding, which are blocked by vagotomy, indicating a neuronal pathway that includes the hepatic vagal afferent nerve plays an important role in the pharmacological actions of DPP-IV inhibitor.
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