Baiyang Sheng, Xinglong Wang, Bo Su, Hyoung-gon Lee, Gemma Casadesus, George Perry and Xiongwei Zhu Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease Journal of Neurochemistry 120
Mitochondrial biogenesis is regulated by the PGC-1α-NRF-TFAM pathway. We found decreased expression of these molecules in both AD hippocampal tissues and APPswe M17 cells. PGC-1α over-expression could completely rescue while PGC-1α knockdown could exacerbate impaired mitochondrial biogenesis and mitochondrial deficits in APPswe cells. Furthermore, the PKA/CREB pathway plays a critical role in the regulation of PGC-1α expression in APPswe cells.
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