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Adjmal Nahimi, Mette Høltzermann, Anne M. Landau, Mette Simonsen, Steen Jakobsen, Aage Kristian Olsen Alstrup, Kim Vang, Arne Møller, Gregers Wegener, Albert Gjedde and Doris J. Doudet Serotonergic modulation of receptor occupancy in rats treated with l-DOPA after unilateral 6-OHDA lesioning Journal of Neurochemistry 120

Article first published online: 23 JAN 2012 | DOI: 10.1111/j.1471-4159.2011.07598.x

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l-DOPA induced dopamine release from serotonergic neurons activate dopamine D2 receptors in Parkinson’s disease The effect of a 5-HT1A agonist on the l-DOPA induced decrease in [11C]raclopride binding was evaluated in an unilateral lesioned animal model of Parkinson’s disease (PD). The baseline increase of [11C]raclopride binding in lesioned striatum was eliminated by the l-DOPA challenge, while the concurrent administration of 8-OHDPAT prevented this. This study concludes that evaluating the effect(s) of pharmacological challenges by one or multiple drugs may be a feasible goal in human subjects with PD.

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