Shigeki Moriguchi, Yasushi Yabuki and Kohji Fukunaga Reduced calcium/calmodulin-dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP-treated mice Journal of Neurochemistry 120
Parkinson’s disease (PD) patients frequently reveal deficit in cognitive functions. Here, we demonstrated that deficits in cognitive functions in MPTP-treated mice were associated with reduced calcium/calmodulin-dependent protein kinase II (CaMKII) autophosphorylation and impaired LTP induction in the hippocampus. Concomitant with impaired LTP induction, CaMKII autophosphorylation was significantly decreased 1 week after MPTP treatment in DG and 3 to 4 weeks after MPTP treatment in CA1 and CA3 region. Thus, DA depletion induced by MPTP causes impairment of hippocampal DG region in early stage and CA1 or CA3 region was observed in the late stage.
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