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Cuiying Liu, Zhifeng Peng, Nan Zhang, Li Yu, Song Han, Dongguo Li and Junfa Li Identification of differentially expressed microRNAs and their PKC-isoform specific gene network prediction during hypoxic pre-conditioning and focal cerebral ischemia of mice Journal of Neurochemistry 120

Version of Record online: 23 JAN 2012 | DOI: 10.1111/j.1471-4159.2011.07624.x

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Differentially expressed miRNAs in cerebral cortex of mice following hypoxic pre-conditioning (HPC) and middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia Differentially expressed miRNAs were identified in cerebral cortex of mice following HPC and MCAO. The miRNA-gene-network of these 19 specified miRNAs target genes of cPKCβII, γ and nPKCε-interacting proteins involved in HPC-induced neuroprotection was predicted using bioinformatics analyses of genome databases. Furthermore, the down-regulated miR-615-3p during HPC had a detrimental effect on the oxygen-glucose deprivation (OGD)-induced N2A cell injury.

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