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Tânia Melo, Romeu A. Videira, Sónia André, Elisabete Maciel, Carla S. Francisco, Ana M. Oliveira-Campos, Lígia M. Rodrigues, Maria R.M. Domingues, Francisco Peixoto and M. Manuel Oliveira Tacrine and its analogues impair mitochondrial function and bioenergetics: a lipidomic analysis in rat brain Journal of Neurochemistry 120

Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1471-4159.2011.07636.x

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Understanding the brain activity of tacrine and related compounds is important to design drugs that improve their therapeutic efficiency for Alzheimer’s disease. We report that tacrine and two tacrine analogues decrease mitochondrial cardiolipin content and increase phosphatidylserines oxidation, which are linked with the loss of respiratory energy control. Although their inhibition on acetylcholinesterase activity might be considered therapeutic, they could also worsen the disease by damaging neural cell respiration.

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