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Kiichiro Okano, Akiko Maeda, Yu Chen, Vishal Chauhan, Johnny Tang, Grazyna Palczewska, Tsutomu Sakai, Hiroshi Tsuneoka, Krzysztof Palczewski and Tadao Maeda Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage Journal of Neurochemistry 121

Article first published online: 9 FEB 2012 | DOI: 10.1111/j.1471-4159.2012.07647.x

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Rods are more susceptible than cones to light-induced damage: implications for human macular diseases We asked whether rods or cones are more susceptible to light-induced, all-trans-retinal-dependent damage and how any difference of susceptibility could affect the pathology of human macular diseases. Rods are more susceptible than cones to light-induced cell death; similar pathological changes were observed in patients with human macular disease. This finding can partially explain initial pathological events of human macular diseases and add to our understanding of these pathologies.

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