João M. N. Duarte and Rolf Gruetter Characterization of cerebral glucose dynamics in vivo with a four-state conformational model of transport at the blood–brain barrier Journal of Neurochemistry 121
Article first published online: 14 MAR 2012 | DOI: 10.1111/j.1471-4159.2012.07688.x
The present study shows that a four-state conformational model allows reliable determination of kinetics of both glucose uptake and consumption upon dynamic simultaneous measurement of plasma and brain glucose concentration changes. This method can therefore be an alternative to other non-invasive standard methods to determine glucose uptake and consumption that mostly relied on the utilization of isotope-enriched glucose or glucose analogs.
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