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Keiko Ohsawa, Tomomi Sanagi, Yasuko Nakamura, Eri Suzuki, Kazuhide Inoue and Shinichi Kohsaka Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration Journal of Neurochemistry 121

Article first published online: 14 MAR 2012 | DOI: 10.1111/j.1471-4159.2012.07693.x

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Process extension and migration of microglia towards injured sites in the brain are triggered by the stimulation of the purinergic receptor P2Y12 with extracellular ATP. Our results indicate that adenosine, a phosphohydrolytic derivative of ATP, promoted P2Y12-mediated process extension and migration through the adenosine A3 receptor. These findings suggest that A3 signaling cooperates with P2Y12 to regulate the chemotactic motion of microglia in response to neuronal damage.

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