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Wen-Tung Wang, Phil Lee, Hung-Wen Yeh, Irina V. Smirnova and In-Young Choi Effects of acute and chronic hyperglycemia on the neurochemical profiles in the rat brain with streptozotocin-induced diabetes detected using in vivo1H MR spectroscopy at 9.4 T Journal of Neurochemistry 121

Version of Record online: 14 MAR 2012 | DOI: 10.1111/j.1471-4159.2012.07698.x

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The cerebral metabolic consequences of untreated hyperglycemia from the onset to the chronic stage were studied in an animal model of diabetes using in vivo1H-MRS. Acute hyperglycemia increased brain glucose, osmolytes and ketone bodies. Chronic hyperglycemia reduced NAA and glutathione levels. Irreversible alterations of neurochemical levels by glycemic normalization indicate the impact of prolonged uncontrolled hyperglycemia on the CNS.

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